1. INTRODUCTION
Locating and Correcting
the Problem
Prevention
2. ABNORMAL PRESSURE
A. No
Pressure Reading, No Flow
B. No
Pressure Reading, Flow Is Normal
C. Steady
High Pressure
D. Steady
Low Pressure
E. Pressure
Climbing
F. Pressure
Dropping to Zero
G. Pressure
Dropping, But Not to Zero
H. Pressure
Cycling
3. LEAKS
A. Leaky
Fittings
B. Leaks
at Pump
C. Injector
Leaks
D. Column
Leaks
E. Detector
Leaks
4. PROBLEMS WITH THE
CHROMATOGRAM
A. Peak
Tailing
B. Peak
Fronting
C. Split
Peaks
D. Distortion
of Larger Peaks
E. Distortion
of Early Peaks
F. Tailing,
Early Peaks More Than Later Ones
G. Increased
Tailing as k′ Increases
H. Acidic
or Basic Peaks Tail
I. Extra
Peaks
J. Retention
Time Drifts
K. Abrupt
Retention Time Changes
L. Baseline
Drift
M. Baseline
Noise (Regular)
N. Baseline
Noise (Irregular)
O. Broad
peaks
P.
Loss of Resolution
Q. All
Peaks Too SmallR. All Peaks Too large
5. PROBLEMS WITH THE
INJECTOR
A. Manual
Injector, Hard to Turn
B. Manual
Injector, Hard to Load
C. Autoinjector,Will
Not Turn
D. Autoinjector,
Other Problems
6. PROBLEMS DETECTED
BY SMELL, SIGHT, OR SOUND
A. Solvent
Smell
B. “Hot”
Smell
C. Abnormal
Meter Readings
D. Warning
Lamps
E. Warning
Buzzers
F. Squeaks
and Squeals
7. KEY PROBLEM AREAS
AND PREVENTIVE MAINTENANCE
A. Reservoir
B. Pump
C. Injector
D. Column
E. Detector
F.
Genera
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